The Rising Tide Against PFAS In Water: How Nanofiber Technology Promises A Cleaner Future


Understanding the Threat of PFAS Contamination

In recent years, the issue of PFAS (Per- and Polyfluoroalkyl Substances) contamination in water has emerged as a significant environmental and public health concern. PFAS, often referred to as "forever chemicals" due to their persistence in the environment, have been linked to a range of adverse health effects, including cancer, immune system effects, and developmental delays in children. A recent study estimates that 200 million Americans could have PFAS in their drinking water at a concentration above levels considered safe 1. As awareness grows, so does the urgency for effective solutions to mitigate the impact of these contaminants in our water supplies.

PFAS compounds have been widely used in various industrial applications and consumer products, such as non-stick cookware, water-repellent fabrics, and firefighting foams, due to their resistance to water, oil, and heat. However, their resilience becomes a double-edged sword when it leads to accumulation in the environment, particularly in water sources. The challenge of removing PFAS from water is compounded by their chemical stability and the vast number of compounds under the PFAS umbrella, each with its unique properties and health implications

Market Size and Regulatory Environment

The market for PFAS remediation technologies is expanding rapidly, driven by increasing regulatory scrutiny and public demand for clean water. In the United States, the Environmental Protection Agency (EPA) has issued health advisories for specific PFAS compounds. Several States in the United States have independently set guidelines for perfluorooctanoic acid (PFOA, 3–35 ng/L) and perfluorooctanesulfonic acid (PFOS, 10–40 ng/L), and the US Environmental Protection Agency (EPA) announced new stricter advisory levels for PFOA (0.004 ng/L) and PFOS (0.02 ng/L) in 2022 2,3. Globally, similar actions are underway, creating a burgeoning market for effective water treatment solutions. The global PFAS treatment market is expected to grow significantly, with projections indicating a multi-billion dollar industry in the coming years.

The Drawbacks of Traditional Methods

While GAC and Ion Exchange Resins have been the cornerstone of water treatment for various pollutants, their effectiveness against PFAS, especially short-chain compounds, is limited. Here's why:

  • Limited Efficacy for Short-Chain PFAS: Short-chain PFAS are more soluble in water, making them harder to capture using GAC or Ion Exchange Resins. These traditional methods, effective against larger molecules, often fail to adequately address the entire spectrum of PFAS compounds, leaving a significant gap in remediation efforts.
  • Challenges in Regeneration: Both GAC and Ion Exchange Resins pose substantial challenges in regeneration. GAC requires high temperatures for regeneration, a process that can degrade its adsorptive capacity over time. Similarly, regenerating Ion Exchange Resins often involves complex chemical treatments, making it a costly and environmentally burdensome process. This difficulty in regeneration not only increases operational costs but also impacts the sustainability of the treatment process.

The Promise of Nanofiber Technology

Enter nanofiber technology - a cutting-edge solution that stands at the forefront of the battle against PFAS contamination. Nanofibers, with their incredibly fine diameters and high surface area-to-volume ratios, offer a new paradigm in water filtration. These fibers can be engineered to target and capture PFAS molecules specifically, offering several advantages over traditional adsorbents like Granular Activated Carbon (GAC):

  • High Efficiency: Nanofibers can be tailored to capture both long-chain and short-chain PFAS compounds, enhancing removal efficiency across a broad spectrum of contaminants.
  • Regeneration Capability: Unlike many conventional materials, nanofiber filters can be designed for regeneration, allowing for repeated use and reducing waste.
  • Customization: The flexibility in the design and functionalization of nanofibers means they can be adapted to target specific PFAS compounds or to meet the needs of different water treatment scenarios.

Looking Ahead: Nanofiber as the Next Generation Solution

As we navigate the complexities of PFAS regulation and seek sustainable solutions, nanofiber technology emerges as a beacon of hope. Its adaptability and efficiency position it as a next-generation tool in our arsenal against PFAS contamination. Recently, Matregenix submitted a proposal (ER25-C3-4589) titled ‘Plasma-Regenerated Low Pressure Drop Nanofiber Filters for Effective, Economical and Long-Lasting PFAS Removal from Water’ to FY25 SERDP Core Solicitation after our pre-proposal was approved by the Strategic Environmental Research and Development Program (SERDP).

The objective of this project is to develop an advanced nanofiber filtration system equipped with plasma assisted regeneration specifically designed for the effective removal of a broad spectrum of PFAS from water. This technology aims to achieve superior adsorption efficacy (> 0.7 mmol/g for short-chain, including PFHxA, PFBS and GenX, and long-chain, including PFOA and PFOS), operational robustness across a range of conditions (pH from 4 - 10), and a sustainable regeneration process (10 cycles), thereby ensuring safe drinking water and compliance with environmental regulations.

In conclusion, this project expects to deliver a reusable and sustainable water treatment solution effectively removing a broad spectrum of PFAs, by developing an advanced nanofiber membrane functionalized with amine and polyethyleneimine (PEI) combined with a novel plasma regeneration process. The anticipated benefits include improved operational robustness and sustainability of PFAs removal in water treatment, reduced health risks for military and civilian personnel, and a decrease in PFAs environmental impacts. Scientifically, the project will advance understanding of PFAS behavior and remediation in microscale, offering insights that could inform broader environmental management practices. Ultimately, this effort seeks to deliver a scalable, cost-effective approach to PFAS removal, to bridge the gaps of the current insufficient removal techniques including granular activated carbon (GAC) and anionic exchange resins (AEX), demonstrating significant potential for enhancing both military readiness and environmental resilience.


1               Andrews, D. Q. & Naidenko, O. V. Population-wide exposure to per-and polyfluoroalkyl substances from drinking water in the United States. Environmental Science & Technology Letters 7, 931-936 (2020).

2               Post, G. B. Recent US State and Federal Drinking Water Guidelines for Per- and Polyfluoroalkyl Substances. Environmental Toxicology and Chemistry 40, 550-563 (2021).

3               Cousins, I. T., Johansson, J. H., Salter, M. E., Sha, B. & Scheringer, M. Outside the Safe Operating Space of a New Planetary Boundary for Per- and Polyfluoroalkyl Substances (PFAS). Environmental Science & Technology 56, 11172-11179 (2022).